A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response

Christina M Wyatt; Steven D Crowley

doi:10.1016/j.kint.2017.10.005

A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response

Kidney Int. 2017 Dec;92(6):1308-1311. doi: 10.1016/j.kint.2017.10.005.

Authors

Christina M Wyatt¹, Steven D Crowley²

Affiliations

¹ Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
² Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA. Electronic address: [email protected].

PMID: 29153132
DOI: 10.1016/j.kint.2017.10.005

Abstract

The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection.

Keywords: chemokine; cytokines; diabetes insipidus; macrophages; pyelonephritis.

Publication types

Comment

MeSH terms

Epithelial Cells
Humans
Kidney Medulla*
Sodium*
Urinary Tract Infections

Substances

Sodium