Understanding mechanisms to promote successful aging in persons living with HIV

Gerome V Escota; Jane A O'Halloran; William G Powderly; Rachel M Presti

doi:10.1016/j.ijid.2017.11.010

Understanding mechanisms to promote successful aging in persons living with HIV

Int J Infect Dis. 2018 Jan:66:56-64. doi: 10.1016/j.ijid.2017.11.010. Epub 2017 Nov 14.

Authors

Gerome V Escota¹, Jane A O'Halloran², William G Powderly², Rachel M Presti²

Affiliations

¹ Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: [email protected].
² Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO, USA.

PMID: 29154830
DOI: 10.1016/j.ijid.2017.11.010

Abstract

The mortality rate associated with HIV infection plummeted after the introduction of effective antiretroviral therapy pioneered two decades ago. As a result, HIV-infected people now have life expectancies comparable to that of HIV-uninfected individuals. Despite this, increased rates of osteoporosis, chronic liver disease, and in particular cardiovascular disease have been reported among people living with HIV infection. With the aging HIV-infected population, the burden of these comorbid illnesses may continue to accrue over time. In this paper, we present an overview of the aging HIV-infected population, its epidemiology and the many challenges faced. How to define and measure successful aging will also be reviewed. Finally, opportunities that may help mitigate the challenges identified and ensure successful aging among people living with HIV infection will be examined.

Keywords: AIDS; Aging; HIV; Successful aging.

Publication types

Review

MeSH terms

Cardiovascular Diseases / complications
Comorbidity
HIV Infections / complications
HIV Infections / epidemiology
HIV Infections / therapy*
Healthy Aging*
Healthy Lifestyle
Humans
Life Expectancy