Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice

Brain Inj. 2018;32(1):113-122. doi: 10.1080/02699052.2017.1380228. Epub 2017 Nov 20.

Abstract

Primary objective: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour.

Research design: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group.

Methods and procedures: We assessed the effects of smTBI and rmTBI using measures of motor performance (Rotarod Test [RT]), anxiety-like behaviour (Elevated Plus Maze [EPM] and Open Field [OF] tests), and spatial memory (Morris Water Maze [MWM]) within 12 days of the final injury. In separate groups of mice, astrocytosis and microglial activation were assessed 24 hours after the final injury using GFAP and IBA-1 immunohistochemistry.

Main outcomes and results: RmTBI impaired spatial memory in the MWM and increased anxiety-like behaviour in the EPM and OFT. In addition, rmTBI elevated GFAP and IBA-1 immunohistochemistry throughout the mouse brain. RmTBI produced astrocytosis and microglial activation, and elicited impaired spatial memory and anxiety-like behaviour.

Conclusions: rmTBI produces acute cognitive and anxiety-like disturbances associated with inflammatory changes in brain regions involved in spatial memory and anxiety.

Keywords: Animal model; anxiety; chronic traumatic encephalopathy; mild traumatic brain injury; spatial memory.

MeSH terms

  • Animals
  • Anxiety / etiology*
  • Anxiety / pathology
  • Anxiety / psychology
  • Astrocytes / pathology
  • Behavior, Animal / physiology*
  • Brain / pathology
  • Brain Concussion / complications*
  • Brain Concussion / pathology
  • Brain Concussion / psychology
  • Encephalitis / etiology*
  • Encephalitis / pathology
  • Encephalitis / psychology
  • Gliosis / etiology
  • Gliosis / pathology
  • Gliosis / psychology
  • Male
  • Maze Learning / physiology
  • Memory Disorders / etiology*
  • Memory Disorders / pathology
  • Memory Disorders / psychology
  • Mice
  • Microglia / pathology
  • Models, Animal
  • Motor Activity / physiology
  • Recurrence
  • Spatial Memory / physiology*