Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes: Potential risks to meiotic maturation

Reprod Toxicol. 2018 Jan:75:56-64. doi: 10.1016/j.reprotox.2017.11.006. Epub 2017 Nov 20.

Abstract

Particulate air pollution (PM 2.5) is a worldwide concern. Growing epidemiological evidence has shown pathophysiological effects of PM 2.5, not only on cardiovascular system but also on reproductive performance. The composition and physicochemical properties of PM 2.5 vary depending on the emission sources, climate conditions, and complex chemical reactions in the air. These factors make it difficult to understand the cause and mechanistic details of the adverse health effects of PM 2.5. Here, we show potential impacts of PM 2.5 on oocyte maturation in mice by utilizing diesel exhaust-derived secondary organic aerosol (SOA), a major component of urban PM 2.5. We found that the SOA destabilized microtubules of mouse oocytes and p-benzoquinone is one of the candidates for the microtubule-destabilizing compounds. We propose that some biologically reactive components of PM 2.5 should be prioritized for the regulation of atmospheric quality.

Keywords: Diesel exhaust; Embryo; Oocyte; PM 2.5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerosols
  • Air Pollutants / chemistry
  • Air Pollutants / toxicity*
  • Animals
  • Benzoquinones / chemistry
  • Benzoquinones / toxicity
  • Female
  • Inhalation Exposure
  • Meiosis / drug effects*
  • Mice, Inbred C57BL
  • Microtubules / drug effects
  • Mitochondria / drug effects
  • Oocytes / cytology
  • Oocytes / drug effects*
  • Particle Size
  • Particulate Matter / chemistry
  • Particulate Matter / toxicity*
  • Quantitative Structure-Activity Relationship
  • Vehicle Emissions / toxicity*
  • Volatile Organic Compounds / chemistry
  • Volatile Organic Compounds / toxicity*

Substances

  • Aerosols
  • Air Pollutants
  • Benzoquinones
  • Particulate Matter
  • Vehicle Emissions
  • Volatile Organic Compounds
  • quinone