Abstract
This study aimed to characterize multidrug-resistant Proteus mirabilis clones carrying a novel class 1 integron-borne blaIMP-1 In1359 was inserted into a large conjugative plasmid that also carried blaCTX-M-2 The production of carbapenemases in Enterobacteriaceae that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.
Keywords:
IMP-1; In1359; KPC-2; Proteus mirabilis; RmtB-1; aacA4-26; class 1 integron; clones; multidrug resistance.
Copyright © 2018 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Brazil / epidemiology
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Carbapenems / pharmacology
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Clone Cells
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Drug Resistance, Multiple, Bacterial / genetics
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Gene Expression Regulation, Bacterial*
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Humans
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Integrons*
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Microbial Sensitivity Tests
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Plasmids / chemistry*
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Plasmids / metabolism
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Polymyxins / pharmacology
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Proteus Infections / drug therapy
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Proteus Infections / epidemiology
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Proteus Infections / microbiology
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Proteus Infections / transmission
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Proteus mirabilis / drug effects
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Proteus mirabilis / enzymology
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Proteus mirabilis / genetics*
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Proteus mirabilis / isolation & purification
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Tertiary Care Centers
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Tigecycline / pharmacology
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Carbapenems
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Polymyxins
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Tigecycline
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beta-lactamase CTX-2
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beta-lactamase IMP-1
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beta-Lactamases