Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne blaIMP-1 in a Tertiary Hospital

Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01321-17. doi: 10.1128/AAC.01321-17. Print 2018 Feb.

Abstract

This study aimed to characterize multidrug-resistant Proteus mirabilis clones carrying a novel class 1 integron-borne blaIMP-1 In1359 was inserted into a large conjugative plasmid that also carried blaCTX-M-2 The production of carbapenemases in Enterobacteriaceae that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.

Keywords: IMP-1; In1359; KPC-2; Proteus mirabilis; RmtB-1; aacA4-26; class 1 integron; clones; multidrug resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Brazil / epidemiology
  • Carbapenems / pharmacology
  • Clone Cells
  • Drug Resistance, Multiple, Bacterial / genetics
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Integrons*
  • Microbial Sensitivity Tests
  • Plasmids / chemistry*
  • Plasmids / metabolism
  • Polymyxins / pharmacology
  • Proteus Infections / drug therapy
  • Proteus Infections / epidemiology
  • Proteus Infections / microbiology
  • Proteus Infections / transmission
  • Proteus mirabilis / drug effects
  • Proteus mirabilis / enzymology
  • Proteus mirabilis / genetics*
  • Proteus mirabilis / isolation & purification
  • Tertiary Care Centers
  • Tigecycline / pharmacology
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Polymyxins
  • Tigecycline
  • beta-lactamase CTX-2
  • beta-lactamase IMP-1
  • beta-Lactamases