Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin

Sayuri Yamazaki; Mizuyu Odanaka; Akiko Nishioka; Saori Kasuya; Hiroaki Shime; Hiroaki Hemmi; Masaki Imai; Dieter Riethmacher; Tsuneyasu Kaisho; Naganari Ohkura; Shimon Sakaguchi; Akimichi Morita

doi:10.4049/jimmunol.1701056

Ultraviolet B-Induced Maturation of CD11b-Type Langerin^- Dendritic Cells Controls the Expansion of Foxp3⁺ Regulatory T Cells in the Skin

J Immunol. 2018 Jan 1;200(1):119-129. doi: 10.4049/jimmunol.1701056. Epub 2017 Nov 20.

Authors

Sayuri Yamazaki¹, Mizuyu Odanaka², Akiko Nishioka³, Saori Kasuya³, Hiroaki Shime², Hiroaki Hemmi^{4

5}, Masaki Imai², Dieter Riethmacher^{6

7}, Tsuneyasu Kaisho^{4

5}, Naganari Ohkura^{8

9}, Shimon Sakaguchi⁸, Akimichi Morita³

Affiliations

¹ Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan; [email protected].
² Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
³ Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
⁴ Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
⁵ Laboratory for Immune Regulation, World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
⁶ Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana 010000, Republic of Kazakhstan.
⁷ School of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom.
⁸ Department of Experimental Immunology, World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; and.
⁹ Department of Frontier Research in Tumor Immunology, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

PMID: 29158419
DOI: 10.4049/jimmunol.1701056

Abstract

Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin^- DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin^- DCs upregulated surface CD86 expression, induced proliferation of Foxp3⁺ regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin^- DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, CD / metabolism
CD11b Antigen / genetics
CD11b Antigen / metabolism
Cell Differentiation
Cell Proliferation
Cells, Cultured
Dendritic Cells / immunology*
Immune Tolerance / genetics
Lectins, C-Type / metabolism
Lymphocyte Activation
Mannose-Binding Lectins / metabolism
Mice
Mice, Inbred C57BL
Skin / pathology*
T-Lymphocytes, Regulatory / immunology*
Transcriptome
Ultraviolet Rays / adverse effects

Substances

Antigens, CD
CD11b Antigen
CD207 protein, human
Lectins, C-Type
Mannose-Binding Lectins