Are most secondary acute lymphoblastic leukemias mixed acute leukemias?

S J Chen; Z Chen; J Derré; M Le Coniat; F Valensi; F Sigaux; R Berger

Are most secondary acute lymphoblastic leukemias mixed acute leukemias?

Nouv Rev Fr Hematol (1978). 1989;31(1):17-22.

Authors

S J Chen¹, Z Chen, J Derré, M Le Coniat, F Valensi, F Sigaux, R Berger

Affiliation

¹ Unité INSERM U 301, CNRS, Paris, France.

PMID: 2915919

Abstract

A case of acute lymphoblastic leukemia (ALL) secondary to X-ray exposure is reported. The lymphoblasts expressed T-cell and myelomonocytic differentiation-related surface antigens. Clonal chromosomal abnormalities including t(2;12)(q25;q13),-10,der(10), del(11)(q14),der(12) and r were observed. A review of the cytogenetic data suggests that most secondary ALLs, with the exception of Burkitt type ALLs, may be biphenotypic or mixed acute leukemias.

Publication types

Case Reports

MeSH terms

Adult
Antigens, Differentiation / analysis
Biomarkers, Tumor / analysis
Female
Gene Rearrangement
Histocompatibility Testing
Humans
Karyotyping
Leukemia, Biphenotypic, Acute / etiology*
Leukemia, Biphenotypic, Acute / genetics
Leukemia, Radiation-Induced / classification*
Leukemia, Radiation-Induced / genetics
Phenotype
Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

Substances

Antigens, Differentiation
Biomarkers, Tumor