YY1 controls Eμ-3'RR DNA loop formation and immunoglobulin heavy chain class switch recombination

Blood Adv. 2016 Nov 29;1(1):15-20. doi: 10.1182/bloodadvances.2016000372.

Abstract

  1. Transcription factor YY1 regulates the IgH Eμ-3′RR long-distance DNA loop without the YY1 transcriptional activation domain.

  2. YY1 constructs that rescue the Eμ-3′RR DNA loop also restore CSR strongly arguing for the necessity of this long-distance DNA loop for CSR.