Quality of life and psychosocial and physical well-being among 1,023 women during their first assisted reproductive technology treatment: secondary outcome to a randomized controlled trial comparing gonadotropin-releasing hormone (GnRH) antagonist and GnRH agonist protocols

Fertil Steril. 2018 Jan;109(1):154-164. doi: 10.1016/j.fertnstert.2017.09.020. Epub 2017 Nov 23.

Abstract

Objective: To compare self-reported quality of life, psychosocial well-being, and physical well-being during assisted reproductive technology (ART) treatment in 1,023 women allocated to either a short GnRH antagonist or long GnRH agonist protocol.

Design: Secondary outcome of a prospective phase 4, open-label, randomized controlled trial. Four times during treatment a questionnaire on self-reported physical well-being was completed. Further, a questionnaire on self-reported quality of life and psychosocial well-being was completed at the day of hCG testing.

Setting: Fertility clinics at university hospitals.

Patient(s): Women referred for their first ART treatment were randomized in a 1:1 ratio and started standardized ART protocols.

Intervention(s): Gonadotropin-releasing hormone analogue; 528 women allocated to a short GnRH antagonist protocol and 495 women allocated to a long GnRH agonist protocol.

Main outcome measure(s): Self-reported quality of life, psychosocial well-being, and physical well-being based on questionnaires developed for women receiving ART treatment.

Result(s): Baseline characteristics were similar, and response rates were 79.4% and 74.3% in the GnRH antagonist and GnRH agonist groups, respectively. Self-reported quality of life during ART treatment was rated similar and slightly below normal in both groups. However, women in the GnRH antagonist group felt less emotional (adjusted odds ratio [AOR] 0.69), less limited in their everyday life (AOR 0.74), experienced less unexpected crying (AOR 0.71), and rated quality of sleep better (AOR 1.55). Further, women receiving GnRH agonist treatment felt worse physically.

Conclusion(s): Women in a short GnRH antagonist protocol rated psychosocial and physical well-being during first ART treatment better than did women in a long GnRH agonist protocol. However, the one item on self-reported general quality of life was rated similarly.

Clinical trial registration number: NCT00756028.

Keywords: GnRH antagonist/GnRH agonist; in vitro fertilization; physical well-being; psychosocial well-being; quality of life.

Publication types

  • Clinical Trial, Phase IV
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adaptation, Psychological
  • Denmark
  • Emotions
  • Female
  • Fertility
  • Fertility Agents, Female / administration & dosage*
  • Fertility Agents, Female / adverse effects
  • Gonadotropin-Releasing Hormone / agonists*
  • Gonadotropin-Releasing Hormone / antagonists & inhibitors*
  • Health Status
  • Hormone Antagonists / administration & dosage*
  • Hormone Antagonists / adverse effects
  • Hospitals, University
  • Humans
  • Infertility / diagnosis
  • Infertility / physiopathology
  • Infertility / psychology
  • Infertility / therapy*
  • Male
  • Mental Health*
  • Pregnancy
  • Prospective Studies
  • Quality of Life*
  • Reproductive Techniques, Assisted / adverse effects
  • Reproductive Techniques, Assisted / psychology*
  • Self Report
  • Sleep
  • Treatment Outcome

Substances

  • Fertility Agents, Female
  • Hormone Antagonists
  • Gonadotropin-Releasing Hormone

Associated data

  • ClinicalTrials.gov/NCT00756028