Although hemophilia B affects 1 in 25,000 males there may be 3 female hemophilia B carriers per affected male. This clinical review highlights the unique challenges faced by hemophilia B carriers including the under-recognition of bleeding symptoms associated with and without FIX deficiency, discrepancies in correlation between genotype and bleeding phenotype and therapeutic considerations utilizing clinical vignettes of common scenarios.
Keywords: haemophilia; haemophilia carriers; review; women with bleeding disorders.
2017 The Authors. Haemophilia Published by John Wiley & Sons Ltd.