Objective: To explore the relationship between waist-to-hip ratio (WHR) and insulin resistance(IR) in non-diabetic normal-weight individuals and investigate how this association differs between male and femalesubjects.
Methods: From June to October, 2012, we performed a cross-sectional survey among 2142 community-based non-diabetic Chinese participants, who were divided into 4 groups according to the gender-specific quartiles of WHR. Homeostatic model assessment of insulin resistance (HOMA-IR), calculated as the product of fasting plasma glucose (mmol/L) and fasting insulin (mU/L) divided by 22.5, was used as the indicator of insulin resistance. Logistic regression models were used to explore the association of WHR with IR in these subjects.
Results: In the unadjusted model, WHR was significantly associated with IR in women (OR=6.60, 95%CI: 2.86-15.26, P<0.001); the association was still significant (OR=3.28, 95%CI: 1.34-8.04, P=0.009) after adjustment for the potential confounders including the history of hypertension, coronary heartdisease, current smoker, physical inactivity, and body mass index.
Conclusion: WHR is independently associated with IR in non-diabetic Chinese women with normal body weight.
目的: 在非糖尿病正常体质量人群中探讨腰臀比与胰岛素抵抗的相关性，比较其在不同性别的差异。
方法: 选择2012年6月~10月我国南方社区居民进行横断面筛查(n=2142)。将参与者分为男性组和女性组，并按腰臀比四分位数将男女各分为4组。HOMA-IR=[空腹血糖(FIG)x空腹胰岛素(FINS)]/22.5，HOMA-IR做为胰岛素抵抗的评价指标。建立Logistic回归模型分析正常体质量人群中腰臀比与胰岛素抵抗的相关性，并比较其在不同性别中的差异。
结果: 男性和女性正常体质量人群中胰岛素抵抗发生率分别为6.95%，11.47%。在女性非校正模型中，腰臀比与胰岛素抵抗显著相关(OR 6.60，95% CI 2.86 to 15.26，P＜0.001)，校正潜在混杂因素如高血压史、冠心病史、吸烟史、锻炼情况、BMI后，二者仍具相关性(OR 3.28，95% CI 1.34 to 8.04，P=0.009)。
结论: 在非糖尿病正常体质量人群中，女性腰臀比是胰岛素抵抗的独立危险因素。