Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis

Braz J Infect Dis. 2018 Jan-Feb;22(1):51-54. doi: 10.1016/j.bjid.2017.10.006. Epub 2017 Nov 26.

Abstract

A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3-14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6-42) days in the polymyxin with other antimicrobial combinations group (p=0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction.

Keywords: AKI; Aminoglicosides; CRE; Polymyxins.

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Aminoglycosides / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Carbapenems / pharmacology
  • Enterobacteriaceae Infections / drug therapy*
  • Enterobacteriaceae Infections / mortality
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Kidney / drug effects*
  • Male
  • Mediastinitis / drug therapy*
  • Mediastinitis / microbiology*
  • Mediastinitis / mortality
  • Microbial Sensitivity Tests
  • Polymyxin B / therapeutic use*
  • Retrospective Studies
  • Risk Assessment
  • Statistics, Nonparametric
  • Treatment Outcome
  • beta-Lactam Resistance / drug effects

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Carbapenems
  • Polymyxin B