Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C InfectionPublished as part of the Biochemistry series "Biochemistry to Bedside"

Biochemistry. 2018 Feb 6;57(5):481-482. doi: 10.1021/acs.biochem.7b01160. Epub 2017 Dec 1.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aminoisobutyric Acids
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Benzimidazoles / pharmacology
  • Benzimidazoles / therapeutic use*
  • Cyclopropanes
  • Drug Combinations
  • Hepacivirus / drug effects*
  • Hepacivirus / metabolism
  • Hepatitis C / drug therapy*
  • Hepatitis C / virology
  • Humans
  • Lactams, Macrocyclic
  • Leucine / analogs & derivatives
  • Proline / analogs & derivatives
  • Pyrrolidines
  • Quinoxalines / pharmacology
  • Quinoxalines / therapeutic use*
  • Serine Proteases / metabolism
  • Sulfonamides / pharmacology
  • Sulfonamides / therapeutic use*
  • Viral Nonstructural Proteins / antagonists & inhibitors
  • Viral Nonstructural Proteins / metabolism

Substances

  • Aminoisobutyric Acids
  • Antiviral Agents
  • Benzimidazoles
  • Cyclopropanes
  • Drug Combinations
  • Lactams, Macrocyclic
  • Pyrrolidines
  • Quinoxalines
  • Sulfonamides
  • Viral Nonstructural Proteins
  • pibrentasvir
  • Proline
  • NS-5 protein, hepatitis C virus
  • NS3-4A serine protease, Hepatitis C virus
  • Serine Proteases
  • Leucine
  • glecaprevir