A Randomized Double-Blinded Placebo-Controlled Intervention Trial of Melatonin for the Prevention of Preeclampsia in Moderate- and High-Risk Women: The MELPOP Trial

Sebastian R Hobson; Euan M Wallace; John C Kingdom; Ryan J Hodges

doi:10.1007/978-1-4939-7498-6_28

A Randomized Double-Blinded Placebo-Controlled Intervention Trial of Melatonin for the Prevention of Preeclampsia in Moderate- and High-Risk Women: The MELPOP Trial

Methods Mol Biol. 2018:1710:347-352. doi: 10.1007/978-1-4939-7498-6_28.

Authors

Sebastian R Hobson¹, Euan M Wallace², John C Kingdom³, Ryan J Hodges²

Affiliations

¹ Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash Health and Monash University, 246 Clayton Road, Clayton, VIC, 3168, Australia. [email protected].
² Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash Health and Monash University, 246 Clayton Road, Clayton, VIC, 3168, Australia.
³ Maternal Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.

PMID: 29197017
DOI: 10.1007/978-1-4939-7498-6_28

Abstract

This chapter describes the methodologies which may be used in the development of a randomized controlled trial investigating a therapy of choice in preventing preeclampsia.

Keywords: Clinical trial; Melatonin; Oxidative stress; Preeclampsia; Prevention.

MeSH terms

Antioxidants / administration & dosage
Antioxidants / therapeutic use*
Double-Blind Method
Female
Humans
Melatonin / administration & dosage
Melatonin / therapeutic use*
Oxidative Stress / drug effects
Placebo Effect
Pre-Eclampsia / metabolism
Pre-Eclampsia / prevention & control*
Pregnancy
Randomized Controlled Trials as Topic / methods*

Substances

Antioxidants
Melatonin