Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

Chem Commun (Camb). 2017 Dec 14;53(100):13359-13362. doi: 10.1039/c7cc08039e.

Abstract

A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.