Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Avital Swisa; Klaus H Kaestner; Yuval Dor

doi:10.1016/j.cmet.2017.11.009

Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Cell Metab. 2017 Dec 5;26(6):809-811. doi: 10.1016/j.cmet.2017.11.009.

Authors

Avital Swisa¹, Klaus H Kaestner², Yuval Dor³

Affiliations

¹ Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
² Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: [email protected].
³ Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address: [email protected].

PMID: 29211979
DOI: 10.1016/j.cmet.2017.11.009

Abstract

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

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MeSH terms

Humans
Insulin-Secreting Cells*
Mutation
Pancreas
Sequence Analysis, RNA
Single-Cell Analysis*