MAIT Cells: A Link between Gut Integrity and Type 1 Diabetes

Elke Gülden; Noah Palm; Kevan C Herold

doi:10.1016/j.cmet.2017.11.007

MAIT Cells: A Link between Gut Integrity and Type 1 Diabetes

Cell Metab. 2017 Dec 5;26(6):813-815. doi: 10.1016/j.cmet.2017.11.007.

Authors

Elke Gülden¹, Noah Palm¹, Kevan C Herold²

Affiliations

¹ Department of Immunobiology, Yale University, New Haven, CT 06520, USA.
² Department of Immunobiology, Yale University, New Haven, CT 06520, USA. Electronic address: [email protected].

PMID: 29211981
DOI: 10.1016/j.cmet.2017.11.007

Abstract

Type 1 diabetes (T1D) is a multifactorial autoimmune disease whose etiology involves complex interactions between the immune system and the intestinal microbiota. Recent studies by Rouxel et al. (2017) suggest that innate-like mucosal-associated invariant T cells (MAIT cells) may link gut integrity, the microbiota, and T1D.

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MeSH terms

Autoimmune Diseases*
Diabetes Mellitus, Type 1*
Gastrointestinal Microbiome*
Humans
Immune System
Mucosal-Associated Invariant T Cells*