Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs

Transfusion. 1989 Mar-Apr;29(3):265-7. doi: 10.1046/j.1537-2995.1989.29389162735.x.

Abstract

In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected individuals is probably very low.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology
  • Acquired Immunodeficiency Syndrome / psychology*
  • Acquired Immunodeficiency Syndrome / transmission
  • Adult
  • Female
  • HIV Antibodies / analysis
  • HIV Seropositivity / diagnosis
  • HIV Seropositivity / epidemiology
  • HIV Seropositivity / psychology*
  • HIV-1*
  • Hemophilia A / complications
  • Hemophilia A / psychology*
  • Humans
  • Middle Aged
  • Sexual Partners*

Substances

  • HIV Antibodies