Progressive multifocal leukoencephalopathy

Tidsskr Nor Laegeforen. 2017 Dec 12;137(23-24). doi: 10.4045/tidsskr.16.1092. Print 2017 Dec 12.
[Article in English, Norwegian]

Abstract

Progressive multifocal leukoencephalopathy is a rare, opportunistic infection of the central nervous system caused by the John Cunningham virus (JCV). There is no effective antiviral treatment available, and restoring immunocompetence is essential for survival. If this occurs too quickly, however, the inflammatory response may prove fatal. This is an up-to-date review of the disorder, intended for clinicians responsible for immunomodulatory therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Female
  • Humans
  • Immunologic Factors / adverse effects
  • JC Virus / isolation & purification
  • Leukoencephalopathy, Progressive Multifocal* / chemically induced
  • Leukoencephalopathy, Progressive Multifocal* / diagnosis
  • Leukoencephalopathy, Progressive Multifocal* / diagnostic imaging
  • Leukoencephalopathy, Progressive Multifocal* / therapy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed

Substances

  • Immunologic Factors