New Metabolites Produced by Cylindrocarpon sp. SY-39 from a Driftwood

Takuma Suzuki; Seiya Yoshida; Takuya Koseki; Takako Aboshi; Tetsuya Murayama; Unang Supratman; Yoshihito Shiono

doi:10.1002/cbdv.201700493

New Metabolites Produced by Cylindrocarpon sp. SY-39 from a Driftwood

Chem Biodivers. 2018 Feb;15(2). doi: 10.1002/cbdv.201700493. Epub 2018 Jan 31.

Authors

Takuma Suzuki¹, Seiya Yoshida¹, Takuya Koseki¹, Takako Aboshi¹, Tetsuya Murayama¹, Unang Supratman², Yoshihito Shiono¹

Affiliations

¹ Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan.
² Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Sumedang, Indonesia.

PMID: 29236361
DOI: 10.1002/cbdv.201700493

Abstract

Four novel compounds, cylindropyrone A (1), 10'-hydroxyilicicolinic acid D (3), cylindrolactones A (4) and B (5), together with known dihydroinfectopyrone (2) were isolated from the culture of Cylindrocarpon sp. SY-39 from a driftwood. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compound 3 showed antimicrobial activity against Staphylococcus aureus with MIC value of 5.0 μg/mL.

Keywords: Cylindrocarpon sp.; cylindrolactones; driftwood; ilicicolinic acid D; infectopyrone.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / metabolism
Anti-Bacterial Agents / pharmacology*
Dose-Response Relationship, Drug
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Pyrones / chemistry
Pyrones / metabolism
Pyrones / pharmacology*
Staphylococcus aureus / drug effects*
Structure-Activity Relationship
Wood / metabolism
Wood / microbiology*

Substances

Anti-Bacterial Agents
Pyrones