Identification of novel recurrent STAT3- RARA fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/ PML- RARA

Blood. 2018 Feb 22;131(8):935-939. doi: 10.1182/blood-2017-09-807370. Epub 2017 Dec 13.

Authors

Li Yao¹, Lijun Wen¹, Nana Wang¹, Tianhui Liu², Yang Xu^{1

2}, Changgeng Ruan¹, Depei Wu^{1

2}, Suning Chen^{1

2}

Affiliations

¹ Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China; and.
² Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.

PMID: 29237593
DOI: 10.1182/blood-2017-09-807370

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Humans
Leukemia, Promyelocytic, Acute / drug therapy
Leukemia, Promyelocytic, Acute / genetics*
Leukemia, Promyelocytic, Acute / pathology
Male
Oncogene Proteins, Fusion / genetics*
Prognosis
Retinoic Acid Receptor alpha / genetics*
STAT3 Transcription Factor / genetics*
Translocation, Genetic*
Young Adult

Substances

Oncogene Proteins, Fusion
RARA protein, human
Retinoic Acid Receptor alpha
STAT3 Transcription Factor
STAT3 protein, human
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein