Aim: This paper is aimed at providing practical recommendations for the management of acute hepatitis C (AHC).
Methods: This is an expert position paper based on the literature revision. Final recommendations were graded by level of evidence and strength of the recommendations.
Results: Treatment of AHC with direct-acting antivirals (DAA) is safe and effective; it overcomes the limitations of INF-based treatments.
Conclusions: Early treatment with DAA should be offered when available.
Keywords: Acute hepatitis C; Direct-acting antivirals; Peginterferon.