Clinical pathologic case report: A 70-year-old man with inflammatory cerebral amyloid angiopathy causing headache, cognitive impairment, and aphasia

J Clin Neurosci. 2018 Mar:49:71-75. doi: 10.1016/j.jocn.2017.12.002. Epub 2017 Dec 14.

Abstract

A 70-year-old man presented with two months of worsening cognitive impairment, hallucinations, and difficulty speaking, with superimposed headaches. Cerebrospinal fluid analysis was notable for lymphocytic pleocytosis and elevated protein. Imaging studies revealed multiple acute and subacute infarcts with cortical microhemorrhages. The patient underwent a stereotactic brain biopsy. In this article, we discuss the patient's differential diagnosis, pathologic findings, ultimate diagnosis, and clinical outcome.

Keywords: CAA; Cerebral amyloid angiopathy; Dementia; Inflammatory CAA; iCAA.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aphasia / cerebrospinal fluid
  • Aphasia / diagnostic imaging*
  • Aphasia / etiology
  • Cerebral Amyloid Angiopathy / cerebrospinal fluid
  • Cerebral Amyloid Angiopathy / complications
  • Cerebral Amyloid Angiopathy / diagnostic imaging*
  • Cognitive Dysfunction / cerebrospinal fluid
  • Cognitive Dysfunction / diagnostic imaging*
  • Cognitive Dysfunction / etiology
  • Diagnosis, Differential
  • Headache / cerebrospinal fluid
  • Headache / diagnostic imaging*
  • Headache / etiology
  • Humans
  • Magnetic Resonance Imaging / trends
  • Male