Immunological bases of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia

Microbes Infect. 2018 Oct-Nov;20(9-10):589-598. doi: 10.1016/j.micinf.2017.11.014. Epub 2017 Dec 15.

Abstract

Malaria and anaemia are key underlying factors for iNTS disease in African children. Knowledge of clinical and epidemiological risk-factors for iNTS disease has not been paralleled by an in-depth knowledge of the immunobiology of the disease. Herein, we review human and animal studies on mechanisms of increased susceptibility to iNTS in children.

Keywords: Anaemia; Children; Immunity; Malaria; Salmonella; Susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anemia / immunology*
  • Animals
  • Child
  • Disease Susceptibility / immunology*
  • Humans
  • Malaria, Falciparum / immunology*
  • Plasmodium falciparum / growth & development
  • Plasmodium falciparum / immunology
  • Plasmodium falciparum / physiology
  • Risk Factors
  • Salmonella / immunology*
  • Salmonella Infections / immunology*