Characteristics and outcomes of hospitalised patients with vertebral fragility fractures: a systematic review

Age Ageing. 2018 Jan 1;47(1):17-25. doi: 10.1093/ageing/afx079.

Abstract

Background: the complex management for patients presenting to hospital with vertebral fragility fractures provides justification for the development of specific services for them. A systematic review was undertaken to determine the incidence of hospital admission, patient characteristics and health outcomes of vertebral fragility fracture patients to inform the development of such a service.

Methods: non-randomised studies of vertebral fragility fracture in hospital were included. Searches were conducted using electronic databases and citation searching of the included papers.

Results: a total of 19 studies were included. The incidence of hospital admission varied from 2.8 to 19.3 per 10,000/year. The average patient age was 81 years, the majority having presented with a fall. A diagnosis of osteoporosis or previous fragility fracture was reported in around one-third of patients. Most patients (75% men and 78% women) had five or more co-pathologies. Most patients were managed non-operatively with a median hospital length of stay of 10 days. One-third of patients were started on osteoporosis treatment. Inpatient and 1-year mortality was between 0.9 and 3.5%, and 20 and 27%, respectively, between 34 and 50% were discharged from hospital to a care facility. Many patients were more dependent with activities of daily living on discharge compared to their pre-admission level. Older age and increasing comorbidities was associated with longer hospital stay and higher mortality.

Conclusion: these findings indicate that specific hospital services for patients with vertebral fragility fractures should take into consideration local hospitalisation rates for the condition, and should be multifaceted-providing access to diagnostic, therapeutic, surgical and rehabilitation interventions.

Keywords: hospital; older people; osteoporosis; vertebral fragility fracture.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Accidental Falls
  • Activities of Daily Living
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Bone Density Conservation Agents / therapeutic use
  • Comorbidity
  • Female
  • Geriatric Assessment
  • Health Services Needs and Demand
  • Hospital Mortality
  • Humans
  • Incidence
  • Length of Stay
  • Male
  • Middle Aged
  • Osteoporotic Fractures / diagnosis
  • Osteoporotic Fractures / mortality
  • Osteoporotic Fractures / physiopathology
  • Osteoporotic Fractures / therapy*
  • Patient Admission*
  • Recovery of Function
  • Risk Factors
  • Spinal Fractures / diagnostic imaging
  • Spinal Fractures / mortality
  • Spinal Fractures / physiopathology
  • Spinal Fractures / therapy*
  • Time Factors
  • Treatment Outcome

Substances

  • Bone Density Conservation Agents