On/off dropped head syndrome: A severe adverse event after prolonged treatment with MEK inhibitor

Eur J Cancer. 2018 Mar:91:174-176. doi: 10.1016/j.ejca.2017.11.027. Epub 2017 Dec 15.
No abstract available

Keywords: Adverse effect; Dropped head; MEK inhibitor; Melanoma; Targeted therapy.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Benzimidazoles / administration & dosage
  • Benzimidazoles / adverse effects*
  • Chemotherapy, Adjuvant
  • GTP Phosphohydrolases / genetics
  • Humans
  • MAP Kinase Kinase Kinases / antagonists & inhibitors*
  • MAP Kinase Kinase Kinases / metabolism
  • Male
  • Melanoma / drug therapy*
  • Melanoma / enzymology
  • Melanoma / genetics
  • Melanoma / secondary
  • Membrane Proteins / genetics
  • Middle Aged
  • Mutation
  • Neck Muscles / diagnostic imaging
  • Neck Muscles / drug effects*
  • Neck Muscles / physiopathology
  • Neuromuscular Diseases / chemically induced*
  • Neuromuscular Diseases / diagnosis
  • Neuromuscular Diseases / physiopathology
  • Protein Kinase Inhibitors / administration & dosage
  • Protein Kinase Inhibitors / adverse effects*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / enzymology
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • Syndrome
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Benzimidazoles
  • Membrane Proteins
  • Protein Kinase Inhibitors
  • binimetinib
  • MAP Kinase Kinase Kinases
  • GTP Phosphohydrolases
  • NRAS protein, human