Chemical constituents from Taraxacum officinale and their α-glucosidase inhibitory activities

Bioorg Med Chem Lett. 2018 Feb 1;28(3):476-481. doi: 10.1016/j.bmcl.2017.12.014. Epub 2017 Dec 8.

Abstract

Three novel butyrolactones (1-3) and butanoates (4-6), namely taraxiroside A-F, were isolated from Taraxacum officinale along with twenty-two known compounds (7-28). Their chemical structures were elucidated by interpretation of spectroscopic data and comparison with those of literatures. All isolates were evaluated for their α-glucosidase inhibitory activities. Novel compounds 1-6 (IC50 145.3-181.3 μM) showed inhibitory activities similar to that of acarbose (IC50 179.9 μM). Compound 7 and 12 were the most potent inhibitor with IC50 values of 61.2 and 39.8 μM respectively. Compounds 2 and 12 showed as mixed-type inhibition, whereas compound 7 and acarbose showed competitive inhibition.

Keywords: Butanoate; Butyrolactone; Mixed-type inhibition; Taraxacum officinale; α-Glucosidase inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Drug
  • Glycoside Hydrolase Inhibitors / chemistry
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Humans
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Structure-Activity Relationship
  • Taraxacum / chemistry*
  • alpha-Glucosidases / metabolism*

Substances

  • Glycoside Hydrolase Inhibitors
  • Plant Extracts
  • alpha-Glucosidases