Development of a One-Pot Four C-C Bond-Forming Sequence Based on Palladium/Ruthenium Tandem Catalysis

Org Lett. 2018 Jan 5;20(1):194-197. doi: 10.1021/acs.orglett.7b03556. Epub 2017 Dec 19.

Abstract

A one-pot four C-C bond-forming sequence has been developed using two distinct transition metal complexes. The sequence entails a double Pd-catalyzed allylic alkylation followed by a Ru-catalyzed ring-closing metathesis and a Pd-catalyzed Heck coupling. The use of various active methylene nucleophiles was examined with yields up to 76% (93% per C-C bond).

Publication types

  • Research Support, Non-U.S. Gov't