Herpes Simplex Neonatorum

With the development of acyclovir in the 1980s, there was a vast improvement in the overall survival of these infected infants. At present, the mortality of infants with disseminated disease has decreased from 85% to 29%, and patients with central nervous system (CNS) disease has decreased from 50% to roughly 4% in industrialized countries. Unfortunately, it remains elevated in developing nations.