PXR: A New Player in Atopic Dermatitis

Landon K Oetjen; Anna M Trier; Brian S Kim

doi:10.1016/j.jid.2017.08.002

PXR: A New Player in Atopic Dermatitis

J Invest Dermatol. 2018 Jan;138(1):8-10. doi: 10.1016/j.jid.2017.08.002.

Authors

Landon K Oetjen¹, Anna M Trier¹, Brian S Kim²

Affiliations

¹ Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA; Center for the Study of Itch, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
² Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA; Center for the Study of Itch, Washington University School of Medicine, St. Louis, Missouri 63110, USA. Electronic address: [email protected].

PMID: 29273149
DOI: 10.1016/j.jid.2017.08.002

Abstract

Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking. Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis. These observations provide new insight into how environmental insults may predispose individuals to atopic dermatitis.

Publication types

Comment

MeSH terms

Dermatitis, Atopic / immunology*
Eczema*
Epidermis
Gene Expression Regulation
Humans

Abstract

Publication types

MeSH terms

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