Abstract
Neuropathic pain (NeP) results from injury to, or disease of, the peripheral or central components of the neural systems involved in pain. In contrast to inflammatory pain, NeP can persist after healing from the initial injury has resolved. Antipyretic agents, such as non-steroidal anti-inflammatory drugs, steroids, and acetaminophen are ineffective, while specific agents such as gabapentinoids, antidepressants, antiepileptics, and opioids are effective in treating NeP. In this review, we address the definition of NeP, pharmacotherapy for NeP in Japan, pain classification, setting goals for successful NeP medication, and the Japanese algorithm for the pharmacotherapy of NeP with specific prescription guidance.
Keywords:
algorithm; analgesics; neuropathic pain; pharmacotherapy.
MeSH terms
-
Aged
-
Algorithms
-
Amines / administration & dosage*
-
Amines / adverse effects
-
Analgesics, Opioid / administration & dosage*
-
Analgesics, Opioid / adverse effects
-
Anticonvulsants / administration & dosage*
-
Anticonvulsants / adverse effects
-
Antidepressive Agents / administration & dosage*
-
Antidepressive Agents / adverse effects
-
Cyclohexanecarboxylic Acids / administration & dosage*
-
Cyclohexanecarboxylic Acids / adverse effects
-
Drug Administration Schedule
-
Duloxetine Hydrochloride / administration & dosage*
-
Duloxetine Hydrochloride / adverse effects
-
Female
-
Gabapentin
-
Humans
-
Japan
-
Neuralgia / classification
-
Neuralgia / drug therapy*
-
Pain Management
-
Pregabalin / administration & dosage*
-
Pregabalin / adverse effects
-
gamma-Aminobutyric Acid / administration & dosage*
-
gamma-Aminobutyric Acid / adverse effects
Substances
-
Amines
-
Analgesics, Opioid
-
Anticonvulsants
-
Antidepressive Agents
-
Cyclohexanecarboxylic Acids
-
Pregabalin
-
gamma-Aminobutyric Acid
-
Gabapentin
-
Duloxetine Hydrochloride