Case Report: Carbapenemase-Producing Enterobacteriaceae in an Asylum Seeker with Multidrug-Resistant Tuberculosis

Sofanne J Ravensbergen; Christina Louka; Mariëtte Lokate; Erik Bathoorn; Spyros Pournaras; Tjip S van der Werf; Wiel C M de Lange; Ymkje Stienstra; Onno W Akkerman

doi:10.4269/ajtmh.17-0544

Case Report: Carbapenemase-Producing Enterobacteriaceae in an Asylum Seeker with Multidrug-Resistant Tuberculosis

Am J Trop Med Hyg. 2018 Feb;98(2):376-378. doi: 10.4269/ajtmh.17-0544. Epub 2017 Dec 21.

Authors

Sofanne J Ravensbergen¹, Christina Louka^{2

1}, Mariëtte Lokate³, Erik Bathoorn³, Spyros Pournaras⁴, Tjip S van der Werf^{5

1}, Wiel C M de Lange^{6

5}, Ymkje Stienstra¹, Onno W Akkerman^{6

5}

Affiliations

¹ University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, The Netherlands.
² Department of Medical Microbiology, Tzaneio General Hospital of Piraeus, Athens, Greece.
³ Department of Medical Microbiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
⁴ Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁵ Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁶ Tuberculosis Center Beatrixoord, University of Groningen, University Medical Center Groningen, Haren, The Netherlands.

Abstract

A Syrian asylum seeker with multidrug-resistant tuberculosis (TB) developed a bronchopleural fistula after pneumonectomy. Although screening tests were negative on admission, carbapenemase-producing Enterobacteriaceae were cultured after a few months of TB treatment. Prevalence of multidrug-resistant organisms is reported to be increased in asylum seekers compared with the general Dutch population. Arduous conditions during transit and interrupted health care delivery in our patient led to multiple-resistant microorganisms that complicated treatment.

Publication types

Case Reports

MeSH terms

Adult
Amikacin / therapeutic use
Carbapenem-Resistant Enterobacteriaceae / drug effects*
Carbapenem-Resistant Enterobacteriaceae / pathogenicity
Clofazimine / therapeutic use
Drug Monitoring / methods
Humans
Linezolid / therapeutic use
Male
Moxifloxacin / therapeutic use
Netherlands
Prevalence
Prothionamide / therapeutic use
Refugees*
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Tuberculosis, Multidrug-Resistant / microbiology*

Substances

Prothionamide
Trimethoprim, Sulfamethoxazole Drug Combination
Amikacin
Clofazimine
Linezolid
Moxifloxacin