Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

Claire Vennin; Kendelle J Murphy; Jennifer P Morton; Thomas R Cox; Marina Pajic; Paul Timpson

doi:10.1053/j.gastro.2017.11.280

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

Gastroenterology. 2018 Mar;154(4):820-838. doi: 10.1053/j.gastro.2017.11.280. Epub 2017 Dec 26.

Authors

Claire Vennin¹, Kendelle J Murphy¹, Jennifer P Morton², Thomas R Cox¹, Marina Pajic³, Paul Timpson⁴

Affiliations

¹ The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
² Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, Scotland, United Kingdom.
³ The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: [email protected].
⁴ The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: [email protected].

PMID: 29287624
DOI: 10.1053/j.gastro.2017.11.280

Abstract

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.

Keywords: Diagnostic Tool; Invasion; Metastasis; Pancreatic Cancer; Patient-Derived Models; Stromal Remodeling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
Biomarkers, Tumor / metabolism
Cell Communication / drug effects
Energy Metabolism / drug effects
Extracellular Matrix / drug effects*
Extracellular Matrix / immunology
Extracellular Matrix / metabolism
Extracellular Matrix / pathology
Humans
Molecular Targeted Therapy
Pancreatic Neoplasms / drug therapy*
Pancreatic Neoplasms / immunology
Pancreatic Neoplasms / metabolism
Pancreatic Neoplasms / pathology
Signal Transduction / drug effects
Stromal Cells / drug effects*
Stromal Cells / immunology
Stromal Cells / metabolism
Stromal Cells / pathology
Tumor Microenvironment*

Substances

Antineoplastic Agents
Biomarkers, Tumor