Out of thin air: Hyperventilation-triggered seizures

Kathryn A Salvati; Mark P Beenhakker

doi:10.1016/j.brainres.2017.12.037

Out of thin air: Hyperventilation-triggered seizures

Brain Res. 2019 Jan 15:1703:41-52. doi: 10.1016/j.brainres.2017.12.037. Epub 2017 Dec 27.

Authors

Kathryn A Salvati¹, Mark P Beenhakker²

Affiliations

¹ Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903, United States.
² Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903, United States. Electronic address: [email protected].

Abstract

Voluntary hyperventilation triggers seizures in the vast majority of people with absence epilepsy. The mechanisms that underlie this phenomenon remain unknown. Herein, we review observations - many made long ago - that provide insight into the relationship between breathing and absence seizures.

Keywords: Circuit; Epilepsy; Respiration; Seizure; Thalamus; pH.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Brain / metabolism
Cerebral Cortex / metabolism
Epilepsy, Absence / metabolism*
Humans
Hyperventilation / metabolism*
Respiration
Seizures / etiology*
Thalamus / metabolism

Abstract

Publication types

MeSH terms

Grants and funding