Objective: To investigate the effect of fried food intake on the pathogenesis of esophageal cancer and precancerous lesions. Methods: From 2005 to 2013, all the residents aged 40-69 years from 11 counties (cities) where cancer screening of upper gastrointestinal cancer had been conducted in rural areas of Henan province, were recruited as the subjects of study. Information on demography and lifestyle was collected. The residents under study were screened with iodine staining endoscopic examination and biopsy samples were diagnosed pathologically, under standardized criteria. Subjects with high risk were divided into the groups based on their different pathological degrees. Multivariate ordinal logistic regression analysis was used to analyze the relationship between the frequency of fried food intake and esophageal cancer and precancerous lesions. Results: A total number of 8 792 cases with normal esophagus, 3 680 with mild hyperplasia, 972 with moderate hyperplasia, 413 with severe hyperplasia carcinoma in situ, and 336 cases of esophageal cancer were recruited. Results from multivariate logistic regression analysis showed that, when compared with those who did not eat fried food, the intake of fried food (<2 times/week: OR=1.60, 95%CI: 1.40-1.83; ≥2 times/week: OR=2.58, 95%CI: 1.98-3.37) appeared a risk factor for both esophageal cancer or precancerous lesions after adjustment for age, sex, marital status, educational level, body mass index, smoking and alcohol intake. Conclusion: The intake of fried food appeared a risk factor for both esophageal cancer and precancerous lesions.
目的： 探讨油炸食品摄入对食管癌及癌前病变发病的影响。 方法： 以2005－2013年在河南省农村地区开展上消化道癌症筛查项目的11个行政县（市）的40~69岁居民为研究对象，收集人口学、生活方式等信息，采用碘染色内镜进行筛查并取活检组织进行病理诊断，依据病理诊断标准分为不同病变等级，并采用多元有序logistic回归分析油炸食品摄入频率与食管癌及癌前病变发病的关系。 结果： 共纳入食管正常8 792例、轻度增生3 680例、中度增生972例、重度增生/原位癌413例、食管癌336例。多因素有序logistic回归分析结果显示，调整年龄、性别、婚姻状况、文化程度、BMI、吸烟和饮酒状况后，油炸食品是食管癌及癌前病变发病的危险因素。与不食油炸食品者相比，当油炸食品摄入频率<2次/周时，其OR值为1.60（95%CI：1.40~1.83）；当油炸食品摄入频率≥2次/周时，其OR值为2.58（95%CI：1.98~3.37）。 结论： 油炸食品摄入是食管癌及癌前病变发病的危险因素。.
Keywords: Esophageal cancer; Fried food; Precancerous lesions.