Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

José A Fernández; Xiao Xu; Ranjeet K Sinha; Laurent O Mosnier; Michel F Sanner; John H Griffin

doi:10.1182/bloodadvances.2017007005

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

Blood Adv. 2017 Aug 7;1(18):1423-1426. doi: 10.1182/bloodadvances.2017007005. eCollection 2017 Aug 8.

Authors

José A Fernández¹, Xiao Xu¹, Ranjeet K Sinha¹, Laurent O Mosnier¹, Michel F Sanner², John H Griffin¹

Affiliations

¹ Department of Molecular Medicine and.
² Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA.

Abstract

Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants.Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.

Abstract

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