Waiting list outcome of Peld/Meld exceptions: A single-center experience in Argentina

Pediatr Transplant. 2018 Mar;22(2). doi: 10.1111/petr.13107. Epub 2018 Jan 3.

Abstract

As PELD/MELD-based allocation policy was adopted in Argentina in 2005, a system of exception points has been in place in order to award increased waitlist priority to those patients whose severity of illness is not captured by the PELD/MELD score. We aimed to investigate the WL outcome of patients with granted PELD/MELD exceptions. A retrospective cohort study was conducted in children under 18 years old. WL outcomes were evaluated using univariable analysis. From 07/2005 to 01/2014, 408 children were listed for LT. There were 304 classified by calculated PELD/MELD. During this time, 85 (30%) PELD/MELD exceptions were granted. In this cohort, 89.4% (76 of 85) were transplanted and 7.1% (6 of 85) died while on the WL. The remaining 3 pts (3.5%) were removed from the WL due to other causes. We compared the impact of PELD/MELD exceptions in those 85 patients to outcomes in 87 non-exception patients with PELD/MELD ≥19 points. Patients with the exception had significantly better access to WL and lower WL mortality. Our data suggest that children listed by PELD/MELD exceptions had an advantage compared to children with CLD with equivalent PELD/MELD listing priorities.

Keywords: exception scores; liver transplantation; pediatric liver allocation.

MeSH terms

  • Adolescent
  • Argentina
  • Child
  • Child, Preschool
  • End Stage Liver Disease / diagnosis*
  • End Stage Liver Disease / mortality
  • End Stage Liver Disease / surgery
  • Female
  • Health Care Rationing / methods*
  • Health Policy
  • Humans
  • Infant
  • Infant, Newborn
  • Liver Transplantation*
  • Male
  • Patient Selection*
  • Retrospective Studies
  • Severity of Illness Index*
  • Waiting Lists / mortality*