BRCA mutations and reproduction

Hagit Daum; Tamar Peretz; Neri Laufer

doi:10.1016/j.fertnstert.2017.12.004

BRCA mutations and reproduction

Fertil Steril. 2018 Jan;109(1):33-38. doi: 10.1016/j.fertnstert.2017.12.004.

Authors

Hagit Daum¹, Tamar Peretz², Neri Laufer³

Affiliations

¹ Department of Genetic and Metabolic Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Electronic address: [email protected].
² Sharett Oncology Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
³ IVF Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

PMID: 29307397
DOI: 10.1016/j.fertnstert.2017.12.004

Abstract

Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as independent risk factors, mostly for breast and ovarian cancer. Numerous studies have evaluated the molecular processes involving these genes, the pathophysiology of BRCAness, follow up options and modes of prophylaxis. The fertility of BRCA carriers, however, has not been widely investigated. The aim of the present work is to review the literature pertaining to this issue.

Keywords: BRCA; preimplantation genetic diagnosis (PGD); premature ovarian insufficiency.

Publication types

Review

MeSH terms

BRCA1 Protein / genetics*
BRCA2 Protein / genetics*
Female
Fertility / genetics*
Fertility Preservation
Genetic Predisposition to Disease
Genetic Testing
Humans
Infertility, Female / epidemiology
Infertility, Female / genetics*
Infertility, Female / physiopathology*
Infertility, Female / therapy
Mutation*
Ovarian Reserve / genetics
Ovary / physiopathology
Phenotype
Preimplantation Diagnosis / methods
Primary Ovarian Insufficiency / epidemiology
Primary Ovarian Insufficiency / genetics*
Primary Ovarian Insufficiency / physiopathology*
Primary Ovarian Insufficiency / therapy
Risk Factors

Substances

BRCA1 Protein
BRCA1 protein, human
BRCA2 Protein
BRCA2 protein, human