Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis

Ronan Shaughnessy; Arnaud Echard

doi:10.1111/tra.12546

Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis

Traffic. 2018 Apr;19(4):247-252. doi: 10.1111/tra.12546. Epub 2018 Feb 11.

Authors

Ronan Shaughnessy¹, Arnaud Echard^{1

2}

Affiliations

¹ Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur, Paris, France.
² Centre National de la Recherche Scientifique UMR3691, Paris, France.

PMID: 29314576
DOI: 10.1111/tra.12546

Abstract

Rab35 is a small GTPase that is involved in many cellular processes, including membrane trafficking, cell polarity, lipid homeostasis, immunity, phagocytosis and cytokinesis. Recent studies showed that activating mutations confer Rab35 with oncogenic properties. Conversely, downregulation of Rab35 inverts apico-basal cell polarity and promotes cell migration. Here we review Rab35's known functions in membrane trafficking and signaling, cell division and cell migration in cancer cells and discuss the importance of Rab35-dependent membrane trafficking in cancer progression.

Keywords: Rab protein; Rab35; cancer; cell migration; cell signaling; cytokinesis; membrane trafficking; tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Movement / physiology*
Cell Polarity / physiology
Humans
Neoplasms / metabolism*
Protein Transport / physiology*
rab GTP-Binding Proteins / metabolism*

Substances

RAB35 protein, human
rab GTP-Binding Proteins