Putting Your Best Egg Forward

Christopher K Patil; Vladimir Denic

doi:10.1016/j.devcel.2017.12.016

Putting Your Best Egg Forward

Dev Cell. 2018 Jan 8;44(1):5-7. doi: 10.1016/j.devcel.2017.12.016. Epub 2018 Jan 8.

Authors

Christopher K Patil¹, Vladimir Denic²

Affiliations

¹ Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
² Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: [email protected].

Abstract

In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lysosomes and mitochondria.

Publication types

Comment

MeSH terms

Fertilization*
Male
Mitochondria
Ovum*
Signal Transduction
Spermatozoa

Grants and funding

R35 GM127136/GM/NIGMS NIH HHS/United States