Thyrotoxic Channelopathies

J Assoc Physicians India. 2017 Nov;65(11):98-99.

Abstract

Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. Early recognition of TPP is vital to initiating appropriate treatment and to avoiding the risk of rebound hyperkalemia that may occur if high-dose potassium replacement is given. Here we present a case of 31 year old male with thyrotoxic periodic paralysis with diagnostic and therapeutic approach.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Arrhythmia Agents / administration & dosage
  • Antithyroid Agents / administration & dosage
  • Atrial Fibrillation* / diagnosis
  • Atrial Fibrillation* / etiology
  • Atrial Fibrillation* / therapy
  • Carbimazole / administration & dosage*
  • Channelopathies* / diagnosis
  • Channelopathies* / etiology
  • Channelopathies* / physiopathology
  • Channelopathies* / therapy
  • Diagnosis, Differential
  • Electrocardiography / methods
  • Humans
  • Hypokalemic Periodic Paralysis* / diagnosis
  • Hypokalemic Periodic Paralysis* / etiology
  • Hypokalemic Periodic Paralysis* / physiopathology
  • Hypokalemic Periodic Paralysis* / therapy
  • Male
  • Muscle Weakness* / diagnosis
  • Muscle Weakness* / therapy
  • Potassium* / administration & dosage
  • Potassium* / blood
  • Potassium* / urine
  • Propranolol / administration & dosage*
  • Thyrotoxicosis* / complications
  • Thyrotoxicosis* / diagnosis
  • Thyrotoxicosis* / drug therapy
  • Treatment Outcome

Substances

  • Anti-Arrhythmia Agents
  • Antithyroid Agents
  • Carbimazole
  • Propranolol
  • Potassium