Adaptation of Staphylococcus aureus to Airway Environments in Patients With Cystic Fibrosis by Upregulation of Superoxide Dismutase M and Iron-Scavenging Proteins

J Infect Dis. 2018 Apr 11;217(9):1453-1461. doi: 10.1093/infdis/jiy012.

Abstract

Adaptation of S. aureus to the hostile environment of CF airways resulted in changed abundance of proteins involved in energy metabolism, cellular processes, transport and binding, but most importantly in an iron-scavenging phenotype and increased activity of superoxide dismutase M.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Biological Transport
  • Carrier Proteins / metabolism
  • Cystic Fibrosis / microbiology*
  • Gene Expression Regulation, Bacterial
  • Humans
  • Iron / metabolism*
  • Respiratory System / microbiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / physiology*
  • Superoxide Dismutase / classification
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism
  • Up-Regulation

Substances

  • Bacterial Proteins
  • Carrier Proteins
  • Iron
  • Superoxide Dismutase