Nucleophosmin-1 regions associated with acute myeloid leukemia interact differently with lipid membranes

Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):967-978. doi: 10.1016/j.bbagen.2018.01.005. Epub 2018 Jan 10.
No abstract available

Keywords: CD spectroscopy; ESR spectroscopy; Nucleophosmin C-terminal domain; Protein-membrane interaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Cell Line, Tumor
  • Cholesterol / metabolism*
  • Circular Dichroism
  • Humans
  • Leukemia, Myeloid / genetics
  • Leukemia, Myeloid / metabolism
  • Leukemia, Myeloid / pathology
  • Lipid Bilayers / metabolism*
  • Membrane Lipids / metabolism*
  • Mutation
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Nucleophosmin
  • Peptides / metabolism
  • Protein Binding
  • Spectrometry, Fluorescence
  • Surface Plasmon Resonance
  • Unilamellar Liposomes / metabolism

Substances

  • Lipid Bilayers
  • Membrane Lipids
  • NPM1 protein, human
  • Nuclear Proteins
  • Peptides
  • Unilamellar Liposomes
  • Nucleophosmin
  • Cholesterol