Photochemically Induced Intramolecular Radical Cyclization Reactions with Imines

J Org Chem. 2018 Feb 16;83(4):1867-1875. doi: 10.1021/acs.joc.7b02810. Epub 2018 Jan 26.

Abstract

The photochemically induced intramolecular hydrogen abstraction or hydrogen atom transfer in cyclic imines 8a,b followed by a cyclization is investigated. Two types of products are observed, one resulting from the formation of a C-C bond, the other from the formation of a C-N bond. A computational study reveals that hydrogen is exclusively transferred to the imine nitrogen leading to a triplet diradical intermediate. After intersystem crossing, the resulting zwitterionic intermediate undergoes cyclization leading to the final product.

Publication types

  • Research Support, Non-U.S. Gov't