Toward an orthogonal central dogma

Chang C Liu; Michael C Jewett; Jason W Chin; Chris A Voigt

doi:10.1038/nchembio.2554

Toward an orthogonal central dogma

Nat Chem Biol. 2018 Jan 16;14(2):103-106. doi: 10.1038/nchembio.2554.

Authors

Chang C Liu¹, Michael C Jewett², Jason W Chin³, Chris A Voigt⁴

Affiliations

¹ Department of Biomedical Engineering, the Department of Chemistry, and the Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
² Department of Chemical and Biological Engineering and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.
³ Medical Research Council Laboratory of Molecular Biology, Cambridge, UK, and the Department of Chemistry, Cambridge University, Cambridge, UK.
⁴ Department of Biological Engineering and the Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Abstract

The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion in the roles of these processes within the cell.

MeSH terms

Biotechnology
DNA Replication*
Genetic Engineering
Humans
Kluyveromyces / genetics
Macromolecular Substances
Mitochondria / metabolism
Plasmids / genetics
Protein Biosynthesis*
Ribosomes / chemistry
Synthetic Biology*
Transcription, Genetic*

Substances

Macromolecular Substances

Abstract

MeSH terms

Substances

Grants and funding