Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation

Matthias P Müller; Daniel Rauh

doi:10.1016/j.chembiol.2018.01.004

Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation

Cell Chem Biol. 2018 Jan 18;25(1):4-6. doi: 10.1016/j.chembiol.2018.01.004.

Authors

Matthias P Müller¹, Daniel Rauh²

Affiliations

¹ Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Straße 4a, 44227 Dortmund, Germany. Electronic address: [email protected].
² Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Straße 4a, 44227 Dortmund, Germany. Electronic address: [email protected].

PMID: 29351837
DOI: 10.1016/j.chembiol.2018.01.004

Abstract

In this issue of Cell Chemical Biology, Bondeson et al. (2018), Burslem et al. (2018), and Huang et al. (2018) systematically characterize proteolysis-targeting chimeras (PROTACs) regarding their specificity and general advantages of targeted proteolysis of cellular proteins and provide interesting insights into possible future developments.

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MeSH terms

Proteins*
Proteolysis*

Substances

Proteins