No Excess Baggage: New Life Starts with a Clean Slate

Netta Shemesh; Anat Ben-Zvi

doi:10.1016/j.molcel.2017.12.033

No Excess Baggage: New Life Starts with a Clean Slate

Mol Cell. 2018 Jan 18;69(2):163-164. doi: 10.1016/j.molcel.2017.12.033.

Authors

Netta Shemesh¹, Anat Ben-Zvi²

Affiliations

¹ National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
² National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel. Electronic address: [email protected].

PMID: 29351841
DOI: 10.1016/j.molcel.2017.12.033

Abstract

A new mechanism for clearing protein damage from maturing oocytes has been described in a recent study by Bohnert and Kenyon (2017), who demonstrated that sperm-secreted hormones activate a vascular H⁺-ATPase pump that acidifies lysosomes and thus restores protein homeostasis.

Publication types

Comment

MeSH terms

Animals
Biological Transport
Caenorhabditis elegans*
Lysosomes
Male
Oocytes
Oxides
Proteostasis*

Substances

Oxides