Laboratory surveillance of antimicrobial resistance and multidrug resistance among Streptococcus pneumoniae isolated in the Kinki region of Japan, 2001-2015

Hirofumi Toda; Kaori Satoh; Masaru Komatsu; Saori Fukuda; Tatsuya Nakamura; Takumi Jikimoto; Hisaaki Nishio; Katsutoshi Yamasaki; Takuya Maede; Tamaki Orita; Noriyuki Sueyoshi; Machiko Kita; Masahiro Toyokawa; Isao Nishi; Masahiro Akagi; Takefumi Higuchi; Tomomi Kofuku; Isako Nakai; Tamotsu Ono; Koichi Shimakawa; Yoshie Hikita; Kunihiko Moro; Kaneyuki Kida; Masanobu Oohama; Yasunao Wada; Toru Tobe; Toshinori Kamisako; Yuji Tanaka

doi:10.1016/j.jiac.2017.12.010

Laboratory surveillance of antimicrobial resistance and multidrug resistance among Streptococcus pneumoniae isolated in the Kinki region of Japan, 2001-2015

J Infect Chemother. 2018 Mar;24(3):171-176. doi: 10.1016/j.jiac.2017.12.010. Epub 2018 Feb 1.

Authors

Hirofumi Toda¹, Kaori Satoh², Masaru Komatsu³, Saori Fukuda⁴, Tatsuya Nakamura⁵, Takumi Jikimoto⁵, Hisaaki Nishio⁶, Katsutoshi Yamasaki⁷, Takuya Maede⁸, Tamaki Orita⁹, Noriyuki Sueyoshi¹⁰, Machiko Kita¹⁰, Masahiro Toyokawa¹¹, Isao Nishi¹², Masahiro Akagi¹³, Takefumi Higuchi¹⁴, Tomomi Kofuku¹⁵, Isako Nakai¹⁵, Tamotsu Ono¹⁶, Koichi Shimakawa¹⁷, Yoshie Hikita¹⁷, Kunihiko Moro¹⁸, Kaneyuki Kida¹⁹, Masanobu Oohama¹⁹, Yasunao Wada²⁰, Toru Tobe²¹, Toshinori Kamisako²², Yuji Tanaka²²

Affiliations

¹ Department of Clinical Laboratory, Kindai University Hospital, Japan; Laboratory of Molecular Medical Microbiology, Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Japan. Electronic address: [email protected].
² Department of Clinical Laboratory, Kindai University Hospital, Japan.
³ Department of Clinical Laboratory Science, Tenri Health Care University, Japan.
⁴ Department of Clinical Pathology, Tenri Hospital, Japan.
⁵ Department of Clinical Laboratory, Kobe University Hospital, Japan.
⁶ Department of Clinical Laboratory, Shiga Medical Center for Adults, Japan.
⁷ Department of Medical Life Science, Kurashiki University of Science and the Arts, Japan.
⁸ Bacteriological Testing Section of the Central Laboratory, FALCO Biosystems Ltd., Japan.
⁹ Department of Clinical Laboratory, Takarazuka City Hospital, Japan.
¹⁰ Department of Clinical Laboratory, Japan Community Health Care Organization Shiga Hospital, Japan.
¹¹ Preparing Section for New Faculty of Medical Sciences, Fukushima Medical University, Japan.
¹² Laboratory for Clinical Investigation, Osaka University Hospital, Japan.
¹³ Department of Clinical Laboratory, Osaka Police Hospital, Japan.
¹⁴ Laboratory for Clinical Investigation, Kyoto University Hospital, Japan.
¹⁵ Department of Clinical Laboratory, Sumitomo Hospital, Japan.
¹⁶ Department of Clinical Laboratory, Japanese Red Cross Kyoto Daini Hospital, Japan.
¹⁷ Satellite Laboratory Testing Unit, Kansai Division, SRL, Inc., Japan.
¹⁸ Department of Clinical Laboratory, Hikone Municipal Hospital, Japan.
¹⁹ Department of Clinical Laboratory, Japanese Red Cross Otsu Hospital, Japan.
²⁰ Department of Clinical Laboratory, Hyogo Medical University Hospital, Japan.
²¹ Laboratory of Molecular Medical Microbiology, Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Japan.
²² Department of Clinical Laboratory Medicine, Kindai University Faculty of Medicine, Japan.

PMID: 29361416
DOI: 10.1016/j.jiac.2017.12.010

Abstract

The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced among children in Japan in 2010. There are no long-term multicenter surveillance studies of antimicrobial resistance in S. pneumoniae before and after the introduction of PCV7. Therefore, we examined chronological trends in antimicrobial resistance among 4534 strains of S. pneumoniae isolated from both children and adults in the Kinki region of Japan during 2001-2015. High-level penicillin and third-generation cephalosporin resistance in S. pneumoniae increased among both children and adults during the period before the introduction of PCV7 (2001-2010). Besides penicillin and cephalosporin, pneumococcal carbapenem and macrolide resistance increased among children. The rate of resistance to these antibiotics was higher among children than among adults. The introduction of PCV7 decreased the rate of non-susceptibility to β-lactam antibiotics and the rate of multidrug resistant S. pneumoniae among children, but not among adults.

Keywords: Multidrug resistance; PCV7; Streptococcus pneumoniae.

Publication types

Multicenter Study

MeSH terms

Adult
Carbapenems / therapeutic use
Cephalosporins / therapeutic use
Child
Drug Resistance, Multiple, Bacterial*
Epidemiological Monitoring
Heptavalent Pneumococcal Conjugate Vaccine / administration & dosage*
Humans
Japan / epidemiology
Macrolides / therapeutic use
Penicillins / therapeutic use
Pneumococcal Infections / drug therapy
Pneumococcal Infections / epidemiology
Pneumococcal Infections / microbiology*
Pneumococcal Infections / prevention & control*
Retrospective Studies
Streptococcus pneumoniae / drug effects
Streptococcus pneumoniae / immunology
Streptococcus pneumoniae / isolation & purification*

Substances

Carbapenems
Cephalosporins
Heptavalent Pneumococcal Conjugate Vaccine
Macrolides
Penicillins