Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease?: An Editorial for 'Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20- APP transgenic and wild-type mice' on doi:10.1111/jnc.14278

Brett Garner; Lezanne Ooi

doi:10.1111/jnc.14276

Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease?: An Editorial for 'Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20- APP transgenic and wild-type mice' on doi:10.1111/jnc.14278

J Neurochem. 2018 Feb;144(4):356-359. doi: 10.1111/jnc.14276. Epub 2018 Jan 26.

Authors

Brett Garner^{1

2}, Lezanne Ooi^{1

2}

Affiliations

¹ Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia.
² School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia.

PMID: 29372570
DOI: 10.1111/jnc.14276

Abstract

This Editorial highlights an article in the current issue by Tapia-Rojas and Inestrosa suggesting that attenuation of Wnt signalling may be a triggering factor for the pathogenesis of Alzheimer disease (AD) in the J20 mouse model of AD. Their study utilises Wnt signalling inhibitors that operate at different points in the signalling pathway. The molecular changes of several key Wnt signaling components are examined, along with a thorough analysis of both the amyloid and tau based pathologies in the mouse brain. Studies focusing on inhibition of Wnt signalling in AD mice have the potential to provide much needed information regarding the pathological mechanisms by which attenuated Wnt signalling impacts on AD.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alzheimer Disease*
Animals
Disease Models, Animal
Mice
Mice, Transgenic
Wnt Signaling Pathway