We provide a consistent mapping of noncollinear two-component quasirelativistic DFT energies with appropriate orientations of localized spinor quantization axes for multinuclear exchange-coupled transition-metal complexes onto an uncoupled anisotropic effective spin Hamiltonian. This provides access to the full exchange interaction tensor between the centers of spin-coupled systems in a consistent way. The proposed methodology may be best viewed as a generalized broken-symmetry density functional theory approach (gBS-DFT). While the calculations provided are limited to trinuclear systems ([M3O(OOCH)6(H2O)3]+, where M = Cr(III), Mn(III), Fe(III)) with C3 symmetry, the method provides a general framework that is extendable to arbitrary systems. It offers an alternative to previous approaches to single-ion zero-field splittings, and it provides access to the less often examined antisymmetric Dzyaloshinskii-Moriya exchange interaction. Spin-orbit coupling is included self-consistently. This will be of particular importance for complexes involving 4d or 5d transition metal centers or possibly also for f-block elements, where a perturbational treatment of spin-orbit coupling may not be valid anymore. While a comparison with experimental data was indirect due to simplifications in the chosen model structures, the agreement obtained indicates the essential soundness of the presented approach.